What Does AST (Aspartate Aminotransferase) Mean?
AST is an enzyme found in liver, muscle, and heart. Elevated AST can signal liver damage, but it also rises after intense exercise or muscle injury.
What AST (Aspartate Aminotransferase) Measures
AST is an enzyme present in the liver but also in muscle, heart, and red blood cells. Doctors typically interpret AST alongside ALT — a high AST/ALT ratio (above 2) can suggest alcoholic liver damage, while AST alone may simply reflect muscle activity.
Normal Ranges
Normal8–48 U/L
Mildly elevated1–3× upper limit
Significantly elevated> 3× upper limit
AST/ALT ratio > 2 (alcohol pattern)—
Reference ranges may vary slightly by lab. Always use the range provided on your specific test report.
What Affects Your AST (Aspartate Aminotransferase) Level
- Liver disease (similar causes as ALT)
- Alcohol use (often raises AST more than ALT)
- Intense exercise or muscle injury
- Heart conditions (less common)
- Hemolysis (red blood cell breakdown)
- Certain medications